Sporopollenin as an efficient green support for covalent immobilization of a lipase

Sporopollenin exine capsules (SECs), derived from the spores of Lycopodium clavatum, have been functionalised with 1,n-diamines and the resulting aminoalkyl microcapsules used to immobilize Candida antarctica lipase B (Cal B) via a glutaradehyde-based diimine covalent linker. The supported enzyme efficiently catalyzes the esterification of oleic acid with ethanol. Initial rates using the SEC-CalBs were comparable to the commercial enzyme Novozym 435, but displayed up to 20-fold higher specific activity. The supported enzymes could also be recycled and after four cycles displayed only a modest decrease in conversions. In a kinetic resolution the SEC-CalBs efficiently acetylated rac-1-phenylethanol, with conversions up to 37% after 5 hours and product enantiomeric excesses of >99%. Related to this, the dynamic resolution of rac-1-phenylethylamine, in the presence of Pd-BaSO₄ and ammonium formate, led to the acetylated amine with a 94% conversion and >99% ee

Software Product Line Engineering via Software Transplantation

For companies producing related products, a Software Product Line (SPL) is a software reuse method that improves time-to-market and software quality, achieving substantial cost reductions.These benefits do not come for free. It often takes years to re-architect and re-engineer a codebase to support SPL and, once adopted, it must be maintained. Current SPL practice relies on a collection of tools, tailored for different reengineering phases, whose output developers must coordinate and integrate. We present Foundry, a general automated approach for leveraging software transplantation to speed conversion to and maintenance of SPL. Foundry facilitates feature extraction and migration. It can efficiently, repeatedly, transplant a sequence of features, implemented in multiple files. We used Foundry to create two valid product lines that integrate features from three real-world systems in an automated way. Moreover, we conducted an experiment comparing Foundry's feature migration with manual effort. We show that Foundry automatically migrated features across codebases 4.8 times faster, on average, than the average time a group of SPL experts took to accomplish the task

Service Provisioning in Edge-Cloud Continuum Emerging Applications for Mobile Devices

Disruptive applications for mobile devices can be enhanced by Edge computing facilities. In this context, Edge Computing (EC) is a proposed architecture to meet the mobility requirements imposed by these applications in a wide range of domains, such as the Internet of Things, Immersive Media, and Connected and Autonomous Vehicles. EC architecture aims to introduce computing capabilities in the path between the user and the Cloud to execute tasks closer to where they are consumed, thus mitigating issues related to latency, context awareness, and mobility support. In this survey, we describe which are the leading technologies to support the deployment of EC infrastructure. Thereafter, we discuss the applications that can take advantage of EC and how they were proposed in the literature. Finally, after examining enabling technologies and related applications, we identify some open challenges to fully achieve the potential of EC, and also research opportunities on upcoming paradigms for service provisioning. This survey is a guide to comprehend the recent advances on the provisioning of mobile applications, as well as foresee the expected next stages of evolution for these applications

Globular clusters in the inner Galaxy classified from dynamical orbital criteria

Globular clusters (GCs) are the most ancient stellar systems in the Milky Way. Therefore, they play a key role in the understanding of the early chemical and dynamical evolution of our Galaxy. Around 40 per cent of them are placed within ∼4 kpc from the Galactic centre. In that region, all Galactic components overlap, making their disentanglement a challenging task. With GaiaData Release 2, we have accurate absolute proper motions for the entire sample of known GCs that have been associated with the bulge/bar region. Combining them with distances, from RR Lyrae when available, as well as radial velocities from spectroscopy, we can perform an orbital analysis of the sample, employing a steady Galactic potential with a bar. We applied a clustering algorithm to the orbital parameters apogalactic distance and the maximum vertical excursion from the plane, in order to identify the clusters that have high probability to belong to the bulge/bar, thick disc, inner halo, or outer halo component. We found that ∼30 per cent of the clusters classified as bulge GCs based on their location are just passing by the inner Galaxy, they appear to belong to the inner halo or thick disc component, instead. Most GCs that are confirmed to be bulge GCs are not following the bar structure and are older than the epoch of the bar formation

Cardiac Impairment Evaluated by Transesophageal Echocardiography and Invasive Measurements in Rats Undergoing Sinoaortic Denervation

Background: Sympathetic hyperactivity may be related to left ventricular (LV) dysfunction and baro- and chemoreflex impairment in hypertension. However, cardiac function, regarding the association of hypertension and baroreflex dysfunction, has not been previously evaluated by transesophageal echocardiography (TEE) using intracardiac echocardiographic catheter.Methods and Results: We evaluated exercise tests, baroreflex sensitivity and cardiovascular autonomic control, cardiac function, and biventricular invasive pressures in rats 10 weeks after sinoaortic denervation (SAD). the rats (n = 32) were divided into 4 groups: 16 Wistar (W) with (n = 8) or without SAD (n = 8) and 16 spontaneously hypertensive rats (SHR) with (n = 8) or without SAD (SHRSAD) (n = 8). Blood pressure (BP) and heart rate (HR) did not change between the groups with or without SAD; however, compared to W, SHR groups had higher BP levels and BP variability was increased. Exercise testing showed that SHR had better functional capacity compared to SAD and SHRSAD. Echocardiography showed left ventricular (LV) concentric hypertrophy; segmental systolic and diastolic biventricular dysfunction; indirect signals of pulmonary arterial hypertension, mostly evident in SHRSAD. the end-diastolic right ventricular (RV) pressure increased in all groups compared to W, and the end-diastolic LV pressure increased in SHR and SHRSAD groups compared to W, and in SHRSAD compared to SAD.Conclusions: Our results suggest that baroreflex dysfunction impairs cardiac function, and increases pulmonary artery pressure, supporting a role for baroreflex dysfunction in the pathogenesis of hypertensive cardiac disease. Moreover, TEE is a useful and feasible noninvasive technique that allows the assessment of cardiac function, particularly RV indices in this model of cardiac disease.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Univ São Paulo, Fac Med, Cardiomyopathy Unit, Heart Inst InCor,Hosp Clin, São Paulo, BrazilUniv São Paulo, Fac Med, Hypertens Unit, Heart Inst InCor,Hosp Clin, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Biosci, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Biosci, São Paulo, BrazilWeb of Scienc

Characterization of volcanic reservoirs; insights from the Badejo and Linguado oil field, Campos Basin, Brazil

Funding Information: This work was financially supported by Petrobras (CENPES – Research Center and Exploration) projects. Especially the authors of Petrobras appreciate the fruitful discussions with the VMAPP Consortium (Volcanic Margin Petroleum Prospectivity) team and workshops. The authors would like to thank also all those who contributed in some way to make this work possible. Dougal A. Jerram and Sverre Plank acknowledge the support from the Research Council of Norway through its Centres of Excellence funding scheme, project 22372 (CEED).Peer reviewedPostprin

UVES analysis of red giants in the bulge globular cluster NGC 6522

Context. NGC 6522 is a moderately metal-poor bulge globular cluster ([Fe/H] ~ −1.0), and it is a well-studied representative among a number of moderately metal-poor blue horizontal branch clusters located in the bulge. The NGC 6522 abundance pattern can give hints on the earliest chemical enrichment in the central Galaxy. Aims. The aim of this study is to derive abundances of the light elements C and N; alpha elements O, Mg, Si, Ca, and Ti; odd-Z elements Na and Al; neutron-capture elements Y, Zr, Ba, La, and Nd; and the r-process element Eu. We verify if there are first- and second-generation stars: we find clear evidence of Na–Al, Na–N, and Mg–Al correlations, while we cannot identify the Na–O anti-correlation from our data. Methods. High-resolution spectra of six red giants in the bulge globular cluster NGC 6522 were obtained at the 8m VLT UT2-Kueyen telescope with both the UVES and GIRAFFE spectrographs in FLAMES+UVES configuration. In light of Gaia data, it turned out that two of them are non-members, but these were also analysed. Spectroscopic parameters were derived through the excitation and ionisation equilibrium of Fe I and Fe II lines from UVES spectra. The abundances were obtained with spectrum synthesis. Comparisons of abundances derived from UVES and GIRAFFE spectra were carried out. Results. The present analysis combined with previous UVES results gives a mean radial velocity of vrhel = −15.62±7.7 km s−1 and a metallicity of [Fe/H] = −1.05 ± 0.20 for NGC 6522. Mean abundances of alpha elements for the present four member stars are enhanced with [O/Fe] = +0.38, [Mg/Fe] = ≈+0.28, [Si/Fe] ≈ +0.19, and [Ca/Fe] ≈ +0.13, together with the iron-peak element [Ti/Fe] ≈ +0.13, and the r-process element [Eu/Fe] = +0.40. The neutron-capture elements Y, Zr, Ba, and La show enhancements in the +0.08 < [Y/Fe] < +0.90, 0.11 < [Zr/Fe] < +0.50, 0.00 < [Ba/Fe] < +0.63, 0.00 < [La/Fe] < +0.45, and −0.10 < [Nd/Fe] < +0.70 ranges. We also discuss the spread in heavy-element abundances

The VISCACHA survey : III. Star clusters counterpart of the Magellanic Bridge and Counter-Bridge in 8D

Context. The interactions between the Small and Large Magellanic Clouds (SMC and LMC) created the Magellanic Bridge; a stream of gas and stars pulled out of the SMC towards the LMC about 150 Myr ago. The tidal counterpart of this structure, which should include a trailing arm, has been predicted by models but no compelling observational evidence has confirmed the Counter-Bridge so far. Aims. The main goal of this work is to find the stellar counterpart of the Magellanic Bridge and Counter-Bridge. We use star clusters in the SMC outskirts as they provide a 6D phase-space vector, age, and metallicity which help characterise the outskirts of the SMC. Methods. Distances, ages, and photometric metallicities were derived from fitting isochrones to the colour-magnitude diagrams from the VISCACHA survey. Radial velocities and spectroscopic metallicities were derived from the spectroscopic follow-up using GMOS in the CaII triplet region. Results. Among the seven clusters analysed in this work, five belong to the Magellanic Bridge, one belongs to the Counter-Bridge, and the other belongs to the transition region. Conclusions. The existence of the tidal counterpart of the Magellanic Bridge is evidenced by star clusters. The stellar component of the Magellanic Bridge and Counter-Bridge are confirmed in the SMC outskirts. These results are an important constraint for models that seek to reconstruct the history of the orbit and interactions between the LMC and SMC as well as constrain their future interaction including with the Milky Way